The consequences of translational and rotational entropy lost by small molecules on binding to proteins
- 1 January 2002
- journal article
- Published by Springer Science and Business Media LLC in Journal of Computer-Aided Molecular Design
- Vol. 16 (10), 741-753
- https://doi.org/10.1023/a:1022446720849
Abstract
When a small molecule binds to a protein, it loses a significant amount of rigid body translational and rotational entropy. Estimates of the associated energy barrier vary widely in the literature...Keywords
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