Relaxation of smooth muscle by cardiodilatin/atrial natriuretic peptide is inhibited by cAMP‐dependent phosphorylation
- 10 December 1987
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 225 (1-2), 251-254
- https://doi.org/10.1016/0014-5793(87)81168-7
Abstract
Cardiodilatins/atrial natriuretic peptides (CDD/ANP) exhibit a common amino acid sequence: Arg101-Arg102-Ser103-Ser104. Cyclic AMP-dependent phosphorylation of Ser104 of atrial peptides with [γ-32P]ATP enables rapid identification of cardiac hormones. The biological activity of in vitro phosphorylated cardiodilatin (CDD-28/α-hANP) is dramatically altered compared to the unphosphorylated peptide: the vasorelaxant effect of cardiodilatin 28 is inhibited upon phosphorylation.Keywords
This publication has 15 references indexed in Scilit:
- Isolation of bovine cardiodilatin by fast protein liquid chromatography and reversed-phase high-performance liquid chromatographyJournal of Chromatography A, 1987
- Chromatographic separation of two heterogeneous forms of the catalytic subunit of cyclic AMP-dependent protein kinase holoenzyme type I and type II from striated muscle of different mammalian speciesArchives of Biochemistry and Biophysics, 1987
- Isolation and structural analysis of the circulating human cardiodilatin (alpha ANP)Klinische Wochenschrift, 1986
- Atrial Natriuretic Factor: A Hormone Produced by the HeartScience, 1985
- Regional vasorelaxant selectivity of atrial natriuretic factor in isolated rabbit vesselsLife Sciences, 1985
- Comparative vasoactive effects of native and synthetic atrial natriuretic factor (ANF)Biochemical and Biophysical Research Communications, 1984
- Purification and complete amino acid sequence of α-human atrial natriuretic polypeptide (α-hANP)Biochemical and Biophysical Research Communications, 1984
- The amino acid sequence of an atrial peptide with potent diuretic and natriuretic propertiesBiochemical and Biophysical Research Communications, 1983
- A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in ratsLife Sciences, 1981