Intracerebral Ganglioneuroblastoma with Intracytoplasmic Microtubular Aggregates: Case Report and Ultrastructural Study

Abstract

Cerebral ganglioneuroblastoma is a rare entity that is not well characterized at the ultrastructural level. We report a case of such a neoplasm with some unique fine structural features. The tumor contains both small cells with little evidence of differentiation and large, bizarre multinucleate cells, many of which contain intracytoplasmic aggregates of 22- to 24-nm micro-tubules that displace the nucleus and cytoplasmic organelles to the periphery of the cell. Inclusions of this type have not previously been described in this entity.