In Vitro Interaction of Terbinafine with Itraconazole against Clinical Isolates of Scedosporium prolificans
- 1 February 2000
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 44 (2), 470-472
- https://doi.org/10.1128/aac.44.2.470-472.2000
Abstract
In order to develop new approaches for the chemotherapy of invasive infections caused by Scedosporium prolificans , the in vitro interaction between itraconazole and terbinafine against 20 clinical isolates was studied using a checkerboard microdilution method. Itraconazole and terbinafine alone were inactive against most isolates, but the combination was synergistic against 95 and 85% of isolates after 48 and 72 h of incubation, respectively. Antagonism was not observed. The MICs obtained with the terbinafine-itraconazole combination were within levels that can be achieved in plasma.Keywords
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