Prospective Clinical Trial on the Efficacy of Amoxycillin Administered Twice or Four Times Daily in Children with Respiratory Tract Infections

Abstract

Thirty-four children with upper or lower respiratory tract infections were randomly allocated to receive either a twice daily or four times daily dose of 50 mg amoxycillin/kg body-weight/day. Mean duration of therapy was identical in both groups. Peak and trough antibiotic concentrations were determined. Eradication of bacteria, clinical improvement and side-effects were comparable in both groups.