Abnormal Calcium Homeostasis in Sarcoidosis

Abstract

Sarcoidosis is a fascinating multifocal disorder of unknown origin,¹ which first attracted the attention of endocrinologists in 1939, when Harrell and Fisher² reported hypercalcemia as a complication in 8 of 11 cases. Since then, it has been observed that mild to severe hypercalcemia may appear, often transiently, in approximately 10 percent of patients and that hypercalciuria is considerably more common.³ In the early 1950s, the efficacy of glucocorticoids in reversing the hypercalcemia and hypercalciuria of sarcoidosis was established.^{4 , 5} O'Leary and colleagues remind us in this issue of the Journal that chloroquine is also effective in the management of sarcoidosis with . . .