Evaluation of effects of a novel endoscopically applied radiofrequency ablation biliary catheter using an ex‐vivo pig liver
- 25 October 2011
- journal article
- research article
- Published by Wiley in Journal of Hepato-Biliary-Pancreatic Sciences
- Vol. 19 (5), 543-547
- https://doi.org/10.1007/s00534-011-0465-7
Abstract
Background The effects of ablation with various settings of powers and times using a newly developed radiofrequency (RF) ablation device, the Habib™ EndoHPB catheter, are not well known. In the present study, we examined the effects of a novel RF ablation catheter using resected fresh pig livers and evaluated the macro‐ and microscopic effects of RF ablation under various conditions. Materials and methods The RF application was performed step by step at 5, 10, 15, and 20 W power and 60, 90, 120 s, respectively. Macroscopic and microscopic findings of the ablation area were evaluated at each setting. Results The mean lengths of the short axis of the ablation area at 10 W and 60, 90 and 120 s were 8.0 ± 1.0, 8.3 ± 1.2, and 9.7 ± 0.6 mm, respectively. The mean lengths of the long axis at 10 W power and 60, 90 and 120 s were 20.3 ± 0.6, 21.3 ± 1.6, and 28.3 ± 2.1 mm, respectively. Although the lengths of the short and long axes at 5 and 10 W increased gradually with power, there were no obvious differences in either short or long axis lengths between 15 and 20 W. Of all the settings, only at 5 W and 60 and 90 s did the long axis of the ablation show separate areas around the 2 ring electrodes. Conclusions Although other sequelae including hemorrhage, pancreatitis, acute inflammatory changes, perforation and late fibrosis could not be investigated in our ex‐vivo pig model, our study clarified the relationship between ablation powers and times and the effects concerning depth and longitudinal spread of ablation. Although the clinical ablation setting at 7–10 W power and 2 min is suitable, ultimately the ablation power and time should be adjusted according to the size of masses using examples from the present results.Keywords
This publication has 13 references indexed in Scilit:
- Analysis of endoscopic management of occluded metal biliary stents at a single tertiary care centerGastrointestinal Endoscopy, 2008
- Covered self-expandable metal stents in pancreatic malignancy regardless of resectability: a new concept validated by a decision analysisEndoscopy, 2007
- Malignant distal biliary obstruction: A systematic review and meta-analysis of endoscopic and surgical bypass resultsCancer Treatment Reviews, 2006
- A prospective randomised study of "covered" versus "uncovered" diamond stents for the management of distal malignant biliary obstructionGut, 2004
- Endoscopic management of occluded biliary Wallstents: a cancer center experienceGastrointestinal Endoscopy, 2003
- Plastic or metal stents for malignant stricture of the common bile duct? Results of a randomized prospective studyGastrointestinal Endoscopy, 2003
- Biliary stents in malignant obstructive jaundice due to pancreatic carcinoma: a cost-effectiveness analysisThe American Journal of Gastroenterology, 2002
- Therapeutic Biliary EndoscopyEndoscopy, 2001
- Randomised trial of endoscopic steriting versus surgical bypass in malignant low bileduct obstructionThe Lancet, 1994
- Endoscopic Biliary Drainage for Severe Acute CholangitisNew England Journal of Medicine, 1992