Clinicopathological significance of stanniocalcin 2 gene expression in colorectal cancer
Open Access
- 11 June 2009
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 125 (4), 926-931
- https://doi.org/10.1002/ijc.24453
Abstract
Laser microdissection (LMD) and microarray were used to identify genes associated with colorectal cancer. Stanniocalcin 2 (STC2) expression and clinicopathological significance in 139 clinical colorectal cancer samples were specifically investigated using real-time quantitative reverse transcription-polymerase chain reaction. A number of genes upregulated in colorectal cancer cells compared to normal colorectal epithelial cells were identified including STC2. STC2 gene expression in cancer tissue was higher than in corresponding normal colorectal epithelial tissue in 124 of 139 cases (89.2%, p < 0.01). Tumors with high STC2 expression showed higher frequencies of lymph node metastasis, lymphatic invasion, tumor depth, tumor size and AJCC Stage classification (p < 0.01). Patients with high STC2 expression also showed significantly worse overall survival rates than those with low STC2 expression (p < 0.01). Furthermore, STC2 gene appeared to be associated with colorectal cancer progression and may be a useful prognostic indicator for colorectal cancer. © 2009 UICCKeywords
This publication has 36 references indexed in Scilit:
- Stanniocalcin 2 expression is regulated by hormone signalling and negatively affects breast cancer cell viability in vitroJournal of Endocrinology, 2008
- Efficient Identification of a Novel Cancer/Testis Antigen for Immunotherapy Using Three-Step Microarray AnalysisCancer Research, 2008
- Cancer Statistics, 2008CA: A Cancer Journal for Clinicians, 2008
- Profiling of selenomethionine responsive genes in colon cancer by microarray analysisCancer Biology & Therapy, 2007
- Opa Interacting Protein 5 (OIP5) Is a Novel Cancer-testis Specific Gene in Gastric CancerAnnals of Surgical Oncology, 2006
- Fatty Acid Binding Protein 6 Is Overexpressed in Colorectal CancerClinical Cancer Research, 2006
- Clinical Significance of Human Kallikrein Gene 6 Messenger RNA Expression in Colorectal CancerClinical Cancer Research, 2005
- Mammalian stanniocalcins and cancer.Endocrine-Related Cancer, 2003
- Stanniocalcin 2: Characterization of the Protein and its Localization to Human Pancreatic Alpha CellsHormone and Metabolic Research, 1999
- Molecular Cloning of a Second Human Stanniocalcin Homologue (STC2)Biochemical and Biophysical Research Communications, 1998