Home administration of lanreotide Autogel® by patients with acromegaly, or their partners, is safe and effective
Open Access
- 20 August 2007
- journal article
- research article
- Published by Wiley in Clinical Endocrinology
- Vol. 68 (3), 343-349
- https://doi.org/10.1111/j.1365-2265.2007.03044.x
Abstract
Objective The introduction of ready‐to‐use lanreotide Autogel® has presented the possibility of patients receiving their acromegaly treatment at home. The objective of this study was to assess the ability of patients (or their partners) to administer repeat, unsupervised, injections of lanreotide Autogel without compromising efficacy or safety. Design Multicentre (10 UK regional endocrine centres), open‐label, nonrandomised, controlled study. Patients elected either to receive/administer unsupervised home injections after injection technique training (Test group) or continued to receive injections from a healthcare professional (Control group). Patients received monthly injections of lanreotide Autogel® at their established dose. Effects were monitored for up to 40 weeks. Patients Thirty patients (15 per treatment group) with acromegaly treated with a stable dose of lanreotide Autogel® (60, 90 or 120 mg) for ≥ 4 months before screening. Measurements The main outcome measure was the proportion of patients/partners who successfully administered injections throughout the study. Results All Test group patients/partners qualified to administer injections. Fourteen of 15 patients fulfilled all criteria for successful administration of unsupervised injections (95% confidence interval, 70%–99%). Fourteen of 15 Test and 14/15 Control patients maintained growth hormone and IGF‐1 control. Local injection tolerability was good for both treatment groups, and safety profiles were similar. All Test group patients continued with unsupervised injections after the study. Conclusions Patients with acromegaly or their partners were able to administer lanreotide Autogel® injections with no detrimental effect on efficacy and safety; therefore, unsupervised home injections are a viable alternative to healthcare professional injections for suitably motivated patients.Keywords
This publication has 10 references indexed in Scilit:
- Effectiveness and tolerability of 3-year lanreotide AutogelR treatment in patients with acromegalyClinical Endocrinology, 2006
- Four-Year Follow-Up of Acromegalic Patients Treated with the New Long-Acting Formulation of Lanreotide (Lanreotide Autogel)Experimental and Clinical Endocrinology & Diabetes, 2005
- Efficacy and tolerability of lanreotide Autogel therapy in acromegalic patients previously treated with octreotide LARActa Endocrinologica, 2004
- One-year follow-up of patients with acromegaly treated with fixed or titrated doses of lanreotide AutogelRClinical Endocrinology, 2004
- Octreotide long-acting repeatable and lanreotide Autogel are equally effective in controlling growth hormone secretion in acromegalic patientsActa Endocrinologica, 2004
- The efficacy and safety of lanreotide Autogel in patients with acromegaly previously treated with octreotide LARActa Endocrinologica, 2004
- Lanreotide Autogel for acromegaly: a new addition to the treatment armamentarium.2004
- Lanreotide Autogel?? for AcromegalyTreatments in Endocrinology, 2004
- Efficacy of the New Long-Acting Formulation of Lanreotide (Lanreotide Autogel) in the Management of AcromegalyJournal of Clinical Endocrinology & Metabolism, 2002
- Efficacy of the New Long-Acting Formulation of Lanreotide (Lanreotide Autogel) in the Management of AcromegalyJournal of Clinical Endocrinology & Metabolism, 2002