Characterization of the Vibrio cholerae vceCAB Multiple-Drug Resistance Efflux Operon in Escherichia coli
Open Access
- 1 August 2005
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 187 (15), 5500-5503
- https://doi.org/10.1128/jb.187.15.5500-5503.2005
Abstract
Herein, we identify vceC as a component of a vceCAB operon, which codes for the Vibrio cholerae VceAB multiple-drug resistance (MDR) efflux pump, and vceR , which codes for a transcriptional autoregulatory protein that negatively regulates the expression of the vceCAB operon and is modulated by some of the substrates of this MDR efflux pump.Keywords
This publication has 22 references indexed in Scilit:
- The Crystal Structure of the Outer Membrane Protein VceC from the Bacterial Pathogen Vibrio cholerae at 1.8 Å ResolutionJournal of Biological Chemistry, 2005
- Crystal Structure of the Drug Discharge Outer Membrane Protein, OprM, of Pseudomonas aeruginosaJournal of Biological Chemistry, 2004
- Evidence that TolC is required for functioning of the Mar/AcrAB efflux pump of Escherichia coliJournal of Bacteriology, 1996
- Multidrug efflux pumps of gram-negative bacteriaJournal of Bacteriology, 1996
- The local repressor AcrR plays a modulating role in the regulation of acrAB genes of Escherichia coli by global stress signalsMolecular Microbiology, 1996
- Multidrug resistance pumps in bacteria: variations on a themeTrends in Biochemical Sciences, 1994
- Multiple antibiotic resistance in Pseudomonas aeruginosa: evidence for involvement of an efflux operonJournal of Bacteriology, 1993
- BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTERAnnual Review of Biochemistry, 1993
- Active efflux mechanisms for antimicrobial resistanceAntimicrobial Agents and Chemotherapy, 1992
- A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes.Proceedings of the National Academy of Sciences, 1985