Immunological Characterization of ConjugatedHaemophilus influenzaeType b Vaccine Failure in Infants
Open Access
- 15 June 2001
- journal article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 32 (12), 1700-1705
- https://doi.org/10.1086/320755
Abstract
Infant vaccination with conjugated Haemophilus influenzae type b (Hib) vaccine is highly effective in protecting against invasive Hib infections, but vaccine failures do occur. Twenty-one vaccine failures are reported since the introduction of the Hib conjugate vaccine in The Netherlands. Of the 14 evaluable patients, 6 children showed no antibody response to Hib polysaccharide in convalescent-phase serum (immunoglobulin [Ig] G anti-Hib level <1.0 µg/mL), including 1 child with hypogammaglobulinemia and 1 child with IgG2 deficiency. After revaccination, almost all children developed anti-Hib antibodies. In case of Hib vaccine failure, case investigation should be performed, including measurement of serum Ig concentrations as well as specific anti-Hib antibodies. Invasive Hib disease after infant conjugate Hib vaccination may be the presentation of an underlying immunodeficiency, but more often, only a decreased antibody response to Hib is found; revaccination with conjugated Hib vaccine is advised.Keywords
This publication has 29 references indexed in Scilit:
- Human IgG Fc ReceptorsInternational Reviews of Immunology, 1997
- The 1996 Albert Lasker Medical Research Awards. Prevention of systemic infections, especially meningitis, caused by Haemophilus influenzae type b. Impact on public health and implications for other polysaccharide-based vaccinesJAMA, 1996
- Haemophilus influenzae type b.Archives of Disease in Childhood, 1993
- G2m(23) Immunoglobulin Allotype and Immunity to Haemophilus influenzae TypebThe Journal of Infectious Diseases, 1992
- Prevention of Haemophilus influenzae Type b Infections in Apache and NavajoChildrenThe Journal of Infectious Diseases, 1992
- The Biology of Haemophilus influenzae Type b Vaccination FailureThe Journal of Infectious Diseases, 1992
- Immunoglobulin deficiency and idiotype expression in children developing Haemophilus influenzae type b disease after vaccination with conjugate vaccine. The Collaborative Study GroupPublished by American Medical Association (AMA) ,1991
- Host and Bacterial Factors Associated with Haemophilus influenzae Type b Disease in Minnesota Children Vaccinated with Type b Polysaccharide VaccineThe Journal of Infectious Diseases, 1989
- Hemophilus Influenzae Type B Disease in Children Vaccinated with Type B Polysaccharide VaccineNew England Journal of Medicine, 1986
- Serum Opsonic Activity for Haemophilus influenzae Type b in Infants Immunized with Polysaccharide-Protein Conjugate VaccinesThe Journal of Infectious Diseases, 1985