Onset of Vulvodynia in a Woman Ultimately Diagnosed With Creutzfeldt-Jakob Disease
- 1 February 2010
- journal article
- case report
- Published by Ovid Technologies (Wolters Kluwer Health) in Obstetrics & Gynecology
- Vol. 115 (2), 423-425
- https://doi.org/10.1097/aog.0b013e3181b80294
Abstract
Vulvodynia, defined as vulvar pain or burning in the presence of normal vulvar appearance, is common and is associated with chronic pain syndromes and psychiatric disorders. A postmenopausal woman complained of vulvar burning. Causes for vulvar burning including yeast infection, estrogen deficiency, and contact dermatitis were excluded. Vulvovaginal examination was normal. Subsequently, she complained of headaches, insomnia, and depression. She developed ataxic gait with rapidly progressive dementia. Brain biopsy confirmed the diagnosis of Creutzfeldt-Jakob disease, and 3 weeks later she lapsed into coma and died. This report is unique in that a rare disease, known to result in neuronal damage, mimicked symptoms of vulvodynia in its initial phase. This supports the hypothesis that vulvodynia is a neuropathic syndrome originating in the nervous system.Keywords
This publication has 6 references indexed in Scilit:
- Creutzfeldt-Jakob disease: a disease overview.American Journal of Electroneurodiagnostic Technology, 2008
- Vulvodynia: New Thoughts on a Devastating ConditionObstetrical & Gynecological Survey, 2007
- VulvostomatodyniaMaturitas, 2007
- Sporadic and familial CJD: classification and characterisationBritish Medical Bulletin, 2003
- Disease associated prion protein may deposit in the peripheral nervous system in human transmissible spongiform encephalopathiesActa Neuropathologica, 1999
- Classification of sporadic Creutzfeldt-Jakob disease based on molecular and phenotypic analysis of 300 subjectsAnnals of Neurology, 1999