Characterization of an Early Activation‐Dependent Antigen on Lymphocytes Defined by the Monoclonal Antibody BL‐Ac(F2)
- 1 January 1994
- journal article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 39 (1), 111-115
- https://doi.org/10.1111/j.1365-3083.1994.tb03348.x
Abstract
A novel activation-dependent lymphocyte cell-surface antigen which is recognized by a MoAb, BL Ac(F2), is described. Although not found on resting lymphocytes the antigen is induced rapidly wiihin 2–4 h following stimulation of the cells using mitogens or antibodies against the T-eell CD3 antigen and sIgM on B cells, respectively. Immunopreeipitation and Western Blotting indicated that the MoAb recognizes a molecule in a range of 78 85 kDa. Beyond its activalion-dependent expression on lymphocytes the antigen was detected also on myelo-monocytic cells. Expression kinetics and cellular distribution of this molecule suggest that it is distinct from previously described activation-dependent cell-surface antigens sueh as CD69, CD25 and 4F2.Keywords
This publication has 19 references indexed in Scilit:
- Identification and characterization of a novel membrane activation antigen with wide cellular distributionEuropean Journal of Immunology, 1988
- Human T cell activation. III. Rapid induction of a phosphorylated 28 kD/32 kD disulfide-linked early activation antigen (EA 1) by 12-o-tetradecanoyl phorbol-13-acetate, mitogens, and antigens.The Journal of Experimental Medicine, 1986
- Detection and functional studies of p60-65 (Tac antigen) on activated human B cells.The Journal of Experimental Medicine, 1984
- Simultaneous flow cytometric analysis of human T cell activation antigen expression and DNA content.The Journal of Experimental Medicine, 1983
- A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptorNature, 1982
- Epstein-Barr virus superinduces a new human b cell differentiation antigen (B-LAST 1) expressed on transformed lymphoblastsCell, 1982
- Biochemical studies of the human thymocyte cell-surface antigens T6, T9 and T10Cell, 1981
- Ia determinants on stimulated human T lymphocytes. Occurrence on mitogen- and antigen-activated T cells.The Journal of Experimental Medicine, 1979
- The insulin receptor as a universal marker of activated lymphocytesEuropean Journal of Immunology, 1978
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970