N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes
- 1 June 2015
- journal article
- Published by Elsevier BV in Chemico-Biological Interactions
- Vol. 234, 18-28
- https://doi.org/10.1016/j.cbi.2014.12.008
Abstract
No abstract availableKeywords
Funding Information
- NIH (R01-AA018123)
This publication has 33 references indexed in Scilit:
- Structural basis of substrate selectivity of Δ1-pyrroline-5-carboxylate dehydrogenase (ALDH4A1): Semialdehyde chain lengthArchives of Biochemistry and Biophysics, 2013
- Aldehyde Dehydrogenase Inhibitors: a Comprehensive Review of the Pharmacology, Mechanism of Action, Substrate Specificity, and Clinical ApplicationPublished by American Society for Pharmacology & Experimental Therapeutics (ASPET) ,2012
- The enzymatic activity of human aldehyde dehydrogenases 1A2 and 2 (ALDH1A2 and ALDH2) is detected by Aldefluor, inhibited by diethylaminobenzaldehyde and has significant effects on cell proliferation and drug resistanceChemico-Biological Interactions, 2012
- Discovery of novel regulators of aldehyde dehydrogenase isoenzymesChemico-Biological Interactions, 2011
- Aldehyde Dehydrogenase Activity of Breast Cancer Stem Cells Is Primarily Due To Isoform ALDH1A3 and Its Expression Is Predictive of MetastasisThe International Journal of Cell Cloning, 2010
- Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use–dependent inhibitor of dopamine synthesisNature Medicine, 2010
- Redox-switch modulation of human SSADH by dynamic catalytic loopThe EMBO Journal, 2009
- Activation of Aldehyde Dehydrogenase-2 Reduces Ischemic Damage to the HeartScience, 2008
- ALDH1 Is a Marker of Normal and Malignant Human Mammary Stem Cells and a Predictor of Poor Clinical OutcomeCell Stem Cell, 2007
- Prospective identification of tumorigenic breast cancer cellsProceedings of the National Academy of Sciences, 2003