3α‐Hydroxysteroid Oxidoreductase in Rat Brain
- 1 March 1984
- journal article
- Published by Wiley in Journal of Neurochemistry
- Vol. 42 (3), 887-890
- https://doi.org/10.1111/j.1471-4159.1984.tb02767.x
Abstract
We describe a simple procedure for the microassay of 3α-hydroxysteroid oxidoreductase in homogenates of rat brain. This enzyme converts dihydrotestosterone to 3α-androstandiol. We have mapped the distribution of the enzymatic activity in 14 regions of the rat brain. The highest activities were observed in homogenates of olfactory bulb (51/nmol/mg protein/h) and olfactory tubercle (29 nmol/mg protein/h). Substantially lower values were seen in the other brain regions, including thalamus, caudate nucleus, frontal cortex, hippocampus, hypothalamus, and preoptic area (6–20 nmol/mg protein/ h).Keywords
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