Stevens‐Johnson Syndrome and Toxic Epidermal Necrolysis Are Severity Variants of the Same Disease which Differs from Erythema Multiforme

Abstract

A new classification, based on the pattern and distribution of cutaneous lesions, separates erythema multiforme major from Stevens‐Johnson syndrome. A retrospective reclassification of 76 cases supported the validity of that separation by demonstrating differing causes and pathology. Another prospective international case‐control study found differing demographic characteristics and risk factors between erythema multiforme major on the one hand and Stevens‐Johnson syndrome or toxic epidermal necrolysis on the other. Erythema multiforme major was mainly related to Herpes virus infection, while Stevens‐Johnson syndrome and toxic epidermal necrolysis were associated with drug reactions.