Wfs1 mutation makes mice sensitive to insulin-like effect of acute valproic acid and resistant to streptozocin
- 2 April 2011
- journal article
- Published by Springer Science and Business Media LLC in Journal of Physiology and Biochemistry
- Vol. 67 (3), 381-390
- https://doi.org/10.1007/s13105-011-0088-0
Abstract
Valproic acid (VLP) is a widely used anticonvulsant and mood-stabilizing drug that relieves the endoplasmic reticulum (ER) stress response, a pathogenetic process related to diabetes. The aim of the present study was to evaluate whether acute valproic acid is able to interfere with glucose intolerance in two different diabetes models: The first model was a Wfs1 mutant mouse with an elevated ER stress response and the second model a streptozocin-induced diabetic mouse. VLP (300 mg/kg, i.p.) was administered to Wfs1 knockout (KO) mice and glucose tolerance test was performed 15 min later. VLP did not have an effect on the course of the glucose tolerance test in wild-type mice, while it did normalize the glucose intolerance in Wfs1 knockout mice. Acute valproic acid also lowered the blood glucose levels in streptozocin-treated mice and potentiated the effect of insulin in these mice. Thus, acute valproic acid is effective in lowering blood glucose levels possibly by potentiating insulin action in both Wfs1 KO mice and in streptozocin-induced type 1 diabetic mice.Keywords
This publication has 51 references indexed in Scilit:
- BioGPS: an extensible and customizable portal for querying and organizing gene annotation resourcesGenome Biology, 2009
- Valproate Attenuates Accelerated Atherosclerosis in Hyperglycemic ApoE-Deficient Mice: Evidence in Support of a Role for Endoplasmic Reticulum Stress and Glycogen Synthase Kinase-3 in Lesion Development and Hepatic SteatosisThe American Journal of Pathology, 2009
- Valproate, a Mood Stabilizer, Induces WFS1 Expression and Modulates Its Interaction with ER Stress Protein GRP94PLOS ONE, 2009
- Expression analysis of G Protein-Coupled Receptors in mouse macrophagesImmunome Research, 2008
- An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and BehaviorCell, 2005
- Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3Journal of Cell Science, 2005
- Disruption of the WFS1 gene in mice causes progressive -cell loss and impaired stimulus-secretion coupling in insulin secretionHuman Molecular Genetics, 2004
- The glamour and gloom of glycogen synthase kinase-3Trends in Biochemical Sciences, 2004
- Psychiatric findings in Wolfram syndrome homozygotesThe Lancet, 1990
- A single therapeutic dose of valproate affects liver carbohydrate, fat, adenylate, amino acid, coenzyme A, and carnitine metabolism in infant mice: Possible clinical significanceLife Sciences, 1985