Protection against peroxynitrite‐dependent tyrosine nitration and α1‐antiproteinase inactivation by oxidized and reduced lipoic acid
- 22 January 1996
- journal article
- Published by Wiley in FEBS Letters
- Vol. 379 (1), 74-76
- https://doi.org/10.1016/0014-5793(95)01489-6
Abstract
Peroxynitrite, formed by combination of superoxide radical with nitric oxide, is a reactive tissue-damaging species apparently involved in the pathology of several human diseases. Peroxynitrite nitrates tyrosine residues and inactivates α 1-antiprotinase. We show that both lipoic acid and dihydrolipoic acid efficiently protect against damage by peroxynitrite. By contrast, other disulphides tested did not. The biological antioxidant effects of lipoate/dihydrolipoate may involve scavenging of reactive nitrogen species as well as reactive oxygen species.Keywords
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