Immunoglobulin heavy chain binding protein
- 1 November 1983
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 306 (5941), 387-389
- https://doi.org/10.1038/306387a0
Abstract
Pre-B lymphocytes, and hybridomas derived from them, synthesize immunoglobulin heavy (IgH) chain in the absence of light (L) chain. In the Abelson virus transformed line 18-81, which is representative of the pre-B cell stage, we observed that at least some of the H-chains are bound to a protein other than L-chain. Here we show that the protein (which we term immunoglobulin heavy-chain binding protein, BiP) binds non-covalently to free IgH, but not to IgH associated with IgL.Keywords
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