Modulation of Epidermal Growth Factor Receptors on 3T3 Cells by Platelet-Derived Growth Factor
- 19 December 1980
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 210 (4476), 1363-1365
- https://doi.org/10.1126/science.6254158
Abstract
Platelet-derived growth factor does not compete with epidermal growth factor (EGF) for binding to EGF receptors on the murine 3T3 cell surface, but it modulates EGF receptors in two ways: (i) it induces a transient down regulation of EGF receptors and (ii) it inhibits EGF-induced down regulation of EGF receptors. These data suggest a common cellular internalization mechanism for the receptors for both hormones.This publication has 20 references indexed in Scilit:
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