Transcutaneous posterior tibial nerve stimulation for treatment of the overactive bladder syndrome in multiple sclerosis: Results of a multicenter prospective study
- 8 February 2011
- journal article
- clinical trial
- Published by Wiley in Neurourology and Urodynamics
- Vol. 30 (3), 306-311
- https://doi.org/10.1002/nau.20958
Abstract
Aims Electrostimulation is an established therapeutic option for neurogenic urinary disorders. The aim of this study was to investigate the efficacy of the noninvasive technique of transcutaneous posterior tibial nerve stimulation (TPTNS) in patients with multiple sclerosis (MS) and troublesome symptoms of an overactive bladder (OAB). Methods A multicentric study enrolled 70 MS patients, suffering from OAB for a 3‐month study period. Intervention: Daily sessions of 20 min of TPTNS were provided. No change of associated treatments during the study period. The primary outcome measurement was Urgency and Frequency reported by bladder diary and symptom score performed before the treatment (Day 0, D0) and at D30 and D90. The secondary outcomes measurements were continence, symptom score, quality of life, psychosocial burden at DO, D30, and D90 and cystometry at baseline, with and without TPTNS and at D90. Results Clinical improvement of OAB was shown in 82.6% and 83.3% of the patients on D30 and D90, respectively, with significant improvement of primary and secondary outcomes compared to baseline. The initial acute cystometric response to TPTNS was positive in 51.2% of the patients (increase of >30% of cystometric capacity and/or reflex volume), without correlation with TPTNS clinical efficiency. The procedure was well tolerated. Conclusions Chronic TPTNS appears to be effective in the management of severe OAB in MS, without compromising bladder emptying or inducing side effect. Treatment may be effective even in the absence of an acute cystometric effect. Additional works are required to demonstrate long‐term efficacy of TPTNS. Neurourol. Urodynam. 30:306–311, 2011.Keywords
This publication has 24 references indexed in Scilit:
- Applications of Neurostimulation for Urinary Storage and Voiding Dysfunction in Neurological PatientsUrologia Internationalis, 2008
- The Effects of Antimuscarinic Treatments in Overactive Bladder: An Update of a Systematic Review and Meta-AnalysisEuropean Urology, 2008
- Prognostic Factors for Successful Percutaneous Tibial Nerve StimulationEuropean Urology, 2006
- Correlation between quality of life and voiding variables in patients treated with percutaneous tibial nerve stimulationBJU International, 2005
- Lower Urinary Tract and Bowel Disorders and Multiple Sclerosis: Role of Sacral Neuromodulation: A Preliminary ReportNeuromodulation: Technology at the Neural Interface, 2005
- Posterior tibial nerve stimulation in the treatment of voiding dysfunction: Urodynamic dataNeurourology and Urodynamics, 2004
- Urodynamic Effect of Acute Transcutaneous Posterior Tibial Nerve Stimulation in Overactive BladderJournal of Urology, 2003
- The standardisation of terminology of lower urinary tract function: Report from the standardisation sub‐committee of the International Continence SocietyNeurourology and Urodynamics, 2002
- PERCUTANEOUS AFFERENT NEUROMODULATION FOR THE REFRACTORY OVERACTIVE BLADDER: RESULTS OF A MULTICENTER STUDYJournal of Urology, 2001
- Rating neurologic impairment in multiple sclerosisNeurology, 1983