Adipogenesis and metabolic health
Top Cited Papers
- 4 January 2019
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Molecular Cell Biology
- Vol. 20 (4), 242-258
- https://doi.org/10.1038/s41580-018-0093-z
Abstract
Obesity is characterized by increased adipose tissue mass and has been associated with a strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public health issue of major proportion. The expansion of adipose depots can be driven either by the increase in adipocyte size (hypertrophy) or by the formation of new adipocytes from precursor differentiation in the process of adipogenesis (hyperplasia). Notably, adipocyte expansion through adipogenesis can offset the negative metabolic effects of obesity, and the mechanisms and regulators of this adaptive process are now emerging. Over the past several years, we have learned a considerable amount about how adipocyte fate is determined and how adipogenesis is regulated by signalling and systemic factors. We have also gained appreciation that the adipogenic niche can influence tissue adipogenic capability. Approaches aimed at increasing adipogenesis over adipocyte hypertrophy can now be explored as a means to treat metabolic diseases.Keywords
This publication has 237 references indexed in Scilit:
- Novel Systemic Therapies in Advanced Liposarcoma: A Review of Recent Clinical Trial ResultsCancers, 2013
- In Vivo Identification of Bipotential Adipocyte Progenitors Recruited by β3-Adrenoceptor Activation and High-Fat FeedingCell Metabolism, 2012
- Zfp423 Expression Identifies Committed Preadipocytes and Localizes to Adipose Endothelial and Perivascular CellsCell Metabolism, 2012
- Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a β-catenin-dependent mechanismBone, 2012
- Mitochondrial Complex III ROS Regulate Adipocyte DifferentiationCell Metabolism, 2011
- Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair CyclingCell, 2011
- Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic MetabolismCell, 2008
- PTRF-Cavin, a Conserved Cytoplasmic Protein Required for Caveola Formation and FunctionCell, 2008
- Transcriptional control of adipocyte formationCell Metabolism, 2006
- Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factorCell, 1994