An asthma clinic was established in the out-patient department of Bellevue Hospital, New York City, in October, 1919. For the year 1919–1920, the scope of the work included a detailed study of the clinical aspects of asthma, which was published (1). During the year 1920–1921 the following investigations were attempted, the results of which are embraced in this paper: (a) A continued study of the clinical considerations of asthma, (b) observations on skin reactions, (c) effects of vaccine therapy. During the year, 105 cases of bronchial asthma were studied in detail; 25 of pollen sensitization; 2 of urticaria, and 2 of angioneurotic edema. Clinical Observations From a practical standpoint, it is important that cases of bronchial asthma be recognized clinically as speedily as possible, since special methods for diagnosis and relief of the condition are attempted. The urgency of the presenting symptom, however, leads to quick transfer to the asthma clinic, when the dyspnea is supposedly asthmatic.