Bile Acid Content of Rat Bile and of Normal and Icteric Rat Plasma

Abstract

The avg. excretion of bile acid in fistula bile was 34.8 mg. at an avg. concn. of 316 mg.% during the 1st 24 hrs. (12 rats) and 8.8 mg. at a concn. of 97 mg. % during the 2d 24 hrs. (7 rats). The plasma bile acid averaged 2.9 mg.% before duct ligation, 17.8 mg.% 24 hrs. after ligation (18 rats), and 8.9 mg.% 48 hrs. after ligation (9 rats). Plasma bile acid averaged 3.2 mg. % before ligation of the bile duct together with simultaneous bilateral nephrectomy, and 68.3 mg.% 24 hrs. after the double operation (12 rats). The values reported cannot be interpreted concerning the presence, absence or amt. of any given bile acid.