Adolescent Obesity and Early-Onset Type 2 Diabetes
- 1 July 2020
- journal article
- research article
- Published by American Diabetes Association in Diabetes Care
- Vol. 43 (7), 1487-1495
- https://doi.org/10.2337/dc19-1988
Abstract
OBJECTIVE Type 2 diabetes (T2D) is increasingly diagnosed at younger ages. We investigated the association of adolescent obesity with incident T2D at early adulthood. RESEARCH DESIGN AND METHODS A nationwide, population-based study evaluated 1,462,362 adolescents (59% men, mean age 17.4 years) during 1996-2016. Data were linked to the Israeli National Diabetes Registry. Weight and height were measured at study entry. Cox proportional models were applied. RESULTS During 15,810,751 person-years, 2,177 people (69% men) developed T2D (mean age at diagnosis 27 years). There was an interaction among BMI, sex, and incident T2D (P-interaction= 0.023). In a model adjusted for sociodemographic variables, the hazard ratios for diabetes diagnosis were 1.7 (95% CI 1.4-2.0), 2.8 (2.3-3.5), 5.8 (4.9-6.9), 13.4 (11.5-15.7), and 25.8 (21.0-31.6) among men in the 50th-74th percentile, 75th-84th percentile, overweight, mild obesity, and severe obesity groups, respectively, and 2.2 (1.6-2.9), 3.4 (2.5-4.6), 10.6 (8.3-13.6), 21.1 (16.0-27.8), and 44.7 (32.4-61.5), respectively, in women. An inverse graded relationship was observed between baseline BMI and mean age of T2D diagnosis: 27.8 and 25.9 years among men and women with severe obesity, respectively, and 29.5 and 28.5 years among low-normal BMI (5th-49th percentile; reference), respectively. The projected fractions of adult-onset T2D that were attributed to high BMI (>= 85th percentile) at adolescence were 56.9% (53.8-59.9%) and 61.1% (56.8-65.2%) in men and women, respectively. CONCLUSIONS Severe obesity significantly increases the risk for incidence of T2D in early adulthood in both sexes. The rise in adolescent severe obesity is likely to increase diabetes incidence in young adults in coming decades.Funding Information
- research grant from the Medical Corps Israel Defense Forces
This publication has 44 references indexed in Scilit:
- Obesity in young men, and individual and combined risks of type 2 diabetes, cardiovascular morbidity and death before 55 years of age: a Danish 33-year follow-up studyBMJ Open, 2013
- Long-Term Risk of Incident Type 2 Diabetes and Measures of Overall and Regional Obesity: The EPIC-InterAct Case-Cohort StudyPLoS Medicine, 2012
- The magnitude of association between overweight and obesity and the risk of diabetes: A meta-analysis of prospective cohort studiesDiabetes Research and Clinical Practice, 2010
- Use of self-reported height and weight biases the body mass index–mortality associationInternational Journal of Obesity, 2010
- The genome-wide structure of the Jewish peopleNature, 2010
- Childhood Size and Life Course Weight Characteristics in Association With the Risk of Incident Type 2 DiabetesDiabetes Care, 2010
- The Burden of Diabetes Mellitus Among US Youth: Prevalence Estimates From the SEARCH for Diabetes in Youth StudyPublished by American Academy of Pediatrics (AAP) ,2006
- Normal Fasting Plasma Glucose Levels and Type 2 Diabetes in Young MenNew England Journal of Medicine, 2005
- Diet, Lifestyle, and the Risk of Type 2 Diabetes Mellitus in WomenNew England Journal of Medicine, 2001
- Obesity, Fat Distribution, and Weight Gain as Risk Factors for Clinical Diabetes in MenDiabetes Care, 1994