Lifespan and Incidence of Cancer and Other Diseases in Selected Long-Lived Inbred Mice and Their F1 Hybrids2

Abstract

Survival patterns and tumor incidence are presented for long-lived mouse strains LP, 129, DBA/2, CBA, C57BL/10, C3H, and C3H.K and 8 derived F₁ hybrid groups. In almost all strains, males lived longer than females. Overall, the F₁ hybrid combinations of noncongenic parents had not only an increased tumor incidence but also an increased lifespan. The lifespan and age-specific incidence of cancer observed for the F₁ hybrids could not be accurately predicted from the parental characteristics.