Clinical evaluation of dietary modification for treatment of spontaneous chronic kidney disease in cats
- 15 September 2006
- journal article
- research article
- Published by American Veterinary Medical Association (AVMA) in Journal of the American Veterinary Medical Association
- Vol. 229 (6), 949-957
- https://doi.org/10.2460/javma.229.6.949
Abstract
Objective—To determine whether a renal diet modified in protein, phosphorus, sodium, and lipid content was superior to an adult maintenance diet in minimizing uremic episodes and mortality rate in cats with stage 2 or 3 chronic kidney disease (CKD). Design—Double-masked, randomized, controlled clinical trial. Animals—45 client-owned cats with spontaneous stage 2 or 3 CKD. Procedures—Cats were randomly assigned to an adult maintenance diet (n = 23 cats) or a renal diet (22) and evaluated trimonthly for up to 24 months. Efficacy of the renal diet, compared with the maintenance diet, in minimizing uremia, renal-related deaths, and all causes of death was evaluated. Results—Serum urea nitrogen concentrations were significantly lower and blood bicarbonate concentrations were significantly higher in the renal diet group at baseline and during the 12- and 24-month intervals. Significant differences were not detected in body weight; Hct; urine protein-to-creatinine ratio; and serum creatinine, potassium, calcium, and parathyroid hormone concentrations. A significantly greater percentage of cats fed the maintenance diet had uremic episodes (26%), compared with cats fed the renal diet (0%). A significant reduction in renal-related deaths but not all causes of death was detected in cats fed the renal diet. Conclusions and Clinical Relevance—The renal diet evaluated in this study was superior to an adult maintenance diet in minimizing uremic episodes and renalrelated deaths in cats with spontaneous stage 2 or 3 CKD.Keywords
This publication has 6 references indexed in Scilit:
- Acid‐base balance of cats with chronic renal failure: effect of deterioration in renal functionJournal of Small Animal Practice, 2003
- Assessment of acid‐base status of cats with naturally occurring chronic renal failureJournal of Small Animal Practice, 2003
- Prevalence of systolic hypertension in cats with chronic renal failure at initial evaluationJournal of the American Veterinary Medical Association, 2002
- Survival of cats with naturally occurring chronic renal failure: effect of dietary managementJournal of Small Animal Practice, 2000
- Dietary considerations for dogs and cats with renal diseaseJournal of the American Veterinary Medical Association, 2000
- Progression of Chronic Renal Disease in the DogJournal of Veterinary Internal Medicine, 1999