HLA typing in Bartter syndrome

Abstract

The mode of inheritance of Bartter syndrome is unclear; however, autosomal recessive inheritance seems likely. A consistent genetic marker of the carrier state likewise remains elusive. HLA typing was done in a family in whom six of 12 sibs have the syndrome. No significant HLA‐syndrome linkage was found. This is in contrast to another familial hypokalemic syndrome in which a significant HLA association was found.