Immunoglobulin E-Mediated Allergies in Lung-Transplanted Adults
- 27 July 2007
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Transplantation
- Vol. 84 (2), 275-279
- https://doi.org/10.1097/01.tp.0000268075.82161.9d
Abstract
Background. Immunoglobulin E (IgE)-mediated allergy has repeatedly been reported after solid organ transplantation, apparently affecting approximately 10% of pediatric organ transplant recipients. Interestingly, type 1 allergy has not been described in transplanted adults, suggesting a particular propensity in childhood. Methods. The present cross-sectional study assessed the prevalence of type 1 allergy in 42 adult lung transplant recipients aged 25 to 50 years. Instruments included standardized interviews, skin prick tests, and serum IgE measurements. Results. Ten of 42 patients (23.8%) displayed elevated specific IgE levels or positive skin prick test results against one or more allergens. Five individuals (11.9%) additionally reported corresponding clinical symptoms of type 1 allergy. No statistically significant association of sensitization or allergy prevalence with patient age, kind of immunosuppressive therapy, and time since transplantation was found. Conclusions. The phenomenon of transplantation-associated allergy is not age-restricted and thus should be assessed more thoroughly in all age groups.Keywords
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