New horizons in the pathogenesis, diagnosis and management of sarcopenia
Open Access
- 11 January 2013
- journal article
- review article
- Published by Oxford University Press (OUP) in Age and Ageing
- Vol. 42 (2), 145-150
- https://doi.org/10.1093/ageing/afs191
Abstract
Sarcopenia is the age-related loss of skeletal muscle mass and function. It is now recognised as a major clinical problem for older people and research in the area is expanding exponentially. One of the most important recent developments has been convergence in the operational definition of sarcopenia combining measures of muscle mass and strength or physical performance. This has been accompanied by considerable progress in understanding of pathogenesis from animal models of sarcopenia. Well-described risk factors include age, gender and levels of physical activity and this knowledge is now being translated into effective management strategies including resistance exercise with recent interest in the additional role of nutritional intervention. Sarcopenia is currently a major focus for drug discovery and development although there remains debate about the best primary outcome measure for trials, and various promising avenues to date have proved unsatisfactory. The concept of ‘new tricks for old drugs’ is, however, promising, for example, there is some evidence that the angiotensin-converting enzyme inhibitors may improve physical performance. Future directions will include a deeper understanding of the molecular and cellular mechanisms of sarcopenia and the application of a lifecourse approach to understanding aetiology as well as to informing the optimal timing of interventions.Keywords
This publication has 50 references indexed in Scilit:
- Hormone Replacement Therapy and Physical Function in Healthy Older Men. Time to Talk Hormones?Endocrine Reviews, 2012
- Nutrition and Sarcopenia: A Review of the Evidence and Implications for Preventive StrategiesJournal of Aging Research, 2012
- Objectively measured physical capability levels and mortality: systematic review and meta-analysisBMJ, 2010
- SarcopeniaBMJ, 2010
- Sarcopenia: characteristics, mechanisms and functional significanceBritish Medical Bulletin, 2010
- Vitamin D-related changes in physical performance: A systematic reviewThe Journal of nutrition, health and aging, 2009
- Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trialsBMJ, 2009
- Of bears, frogs, meat, mice and men: complexity of factors affecting skeletal muscle mass and fatBioEssays, 2006
- The Healthcare Costs of Sarcopenia in the United StatesJournal of the American Geriatrics Society, 2003
- Orally Administered Leucine Enhances Protein Synthesis in Skeletal Muscle of Diabetic Rats in the Absence of Increases in 4E-BP1 or S6K1 PhosphorylationDiabetes, 2002