ELEVATED LEVELS OF THE 26K HUMAN HYBRIDOMA GROWTH-FACTOR (INTERLEUKIN-6) IN CEREBROSPINAL-FLUID OF PATIENTS WITH ACUTE INFECTION OF THE CENTRAL NERVOUS-SYSTEM
- 1 February 1988
- journal article
- research article
- Vol. 71 (2), 320-323
Abstract
We reported recently that a human protein, previously described as IL-1 inducible 26K factor (26K) or interferon-.beta.2, was a potent growth factor for B cell hybridomas in vitro. Subsequently, it appeared that this protein was also identical with the lymphokine B cell stimulatory factor 2. Here we report that the levels of 26K are considerably increased during the early stages of acute infections of the central nervous stystem. This elevation in 26K titres was not observed in either chronic infections or in non-infectious diseases.This publication has 13 references indexed in Scilit:
- Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor.The Journal of Experimental Medicine, 1987
- Interleukin-HP1, a T cell-derived hybridoma growth factor that supports the in vitro growth of murine plasmacytomas.The Journal of Experimental Medicine, 1987
- Thymus grafts induce B cell development in nude, X-linked immune deficient miceEuropean Journal of Immunology, 1987
- Interleukin 1 and poly(rI) · poly(rC) induce production of a hybridoma growth factor by human fibroblastsEuropean Journal of Immunology, 1987
- Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas.Proceedings of the National Academy of Sciences, 1986
- Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulinNature, 1986
- Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines.The EMBO Journal, 1986
- Structural analysis of the sequence coding for an inducible 26‐kDa protein in human fibroblastsEuropean Journal of Biochemistry, 1986
- [6] Particle counting immunoassay (PACIA)Methods in enzymology, 1981