The Tricarboxylic Acid Cycle in Cyanobacteria
- 16 December 2011
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 334 (6062), 1551-1553
- https://doi.org/10.1126/science.1210858
Abstract
It is generally accepted that cyanobacteria have an incomplete tricarboxylic acid (TCA) cycle because they lack 2-oxoglutarate dehydrogenase and thus cannot convert 2-oxoglutarate to succinyl–coenzyme A (CoA). Genes encoding a novel 2-oxoglutarate decarboxylase and succinic semialdehyde dehydrogenase were identified in the cyanobacterium Synechococcus sp. PCC 7002. Together, these two enzymes convert 2-oxoglutarate to succinate and thus functionally replace 2-oxoglutarate dehydrogenase and succinyl-CoA synthetase. These genes are present in all cyanobacterial genomes except those of Prochlorococcus and marine Synechococcus species. Closely related genes occur in the genomes of some methanogens and other anaerobic bacteria, which are also thought to have incomplete TCA cycles.Keywords
This publication has 20 references indexed in Scilit:
- The Danger of Annotation by Analogy: Most “ thiI ” Genes Play No Role in Thiamine BiosynthesisJournal of Bacteriology, 2011
- Large Improvements in MS/MS-Based Peptide Identification Rates using a Hybrid AnalysisJournal of Proteome Research, 2011
- Regulation of nitrate assimilation in cyanobacteriaJournal of Experimental Botany, 2011
- Metabolic and Transcriptomic Phenotyping of Inorganic Carbon Acclimation in the Cyanobacterium Synechococcus elongatus PCC 7942Plant Physiology, 2011
- Transcription Profiling of the Model Cyanobacterium Synechococcus sp. Strain PCC 7002 by Next-Gen (SOLiD™) Sequencing of cDNAFrontiers in Microbiology, 2011
- Genome‐scale modeling of Synechocystis sp. PCC 6803 and prediction of pathway insertionJournal of Chemical Technology & Biotechnology, 2008
- Evaluation of central metabolism based on a genomic database ofSynechocystis PCC6803Biotechnology and Bioprocess Engineering, 2007
- Mechanisms of acetohydroxyacid synthasesCurrent Opinion in Chemical Biology, 2005
- A challenge for 21st century molecular biology and biochemistry: what are the causes of obligate autotrophy and methanotrophy?FEMS Microbiology Reviews, 2004
- Occurrence of thiamin pyrophosphate‐dependent 2‐oxoglutarate decarboxylase in mitochondria of Euglena gracilisFEBS Letters, 1986