Surface antibodies of human myelogenous leukaemia leukocytes reactive with specific type-C viral reverse transcriptases
- 1 November 1978
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 276 (5685), 230-236
- https://doi.org/10.1038/276230a0
Abstract
Purified immunoglobin (Ig) G from patients with chronic myelogenous leukemia specifically neutralized RT [reverse transcriptase] from feline leukemia virus while purified IgG from other types of leukemias and from normal blood cells were less reactive and in some cases preferentially reacted with RT from horizontally transmitted primate type-C viruses (simian sarcoma virus-gibbon ape leukemia virus group). This indicates the presence of a heterogeneous immune response to RT or to an RT-like molecule in humans.Keywords
This publication has 46 references indexed in Scilit:
- Surface immunoglobulins and protease inhibitors of human acute leukemia blastsInternational Journal of Cancer, 1977
- DNA polymerase γ of human lymphoblastsBiochemistry, 1977
- Serological analysis of cellular and viral DNA polymerases by an antiserum to DNA polymerase γ of human lymphoblastsBiochemistry, 1977
- Nucleic acid sequences of primate type C viruses in normal and neoplastic human tissuesNature, 1977
- Proviral sequences of baboon endogenous type C RNA virus in DNA of human leukaemic tissuesNature, 1976
- Inhibition of reverse transcriptases of primate type C viruses by 7S immunoglobulin from patients with leukaemiaNature, 1976
- Membrane-bound immunoglobulins on human leukemic cells. Evidence for humoral immune responses of patients to leukemia-associated antigens.JCI Insight, 1975
- Immunological Relationship of DNA Polymerase from Human Acute Leukaemia Cells and Primate and Mouse Leukaemia Virus Reverse TranscriptaseNature, 1973
- Growth of Feline Leukaemia Virus in Human CellsNature, 1969
- Properties of the Major Component of a Peptic Digest of Rabbit AntibodyScience, 1960