The Effect of 6-Mercaptopurine on Immune Response in Man

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Abstract
The immunosuppressive effects of certain antitumor agents have been known for more than a decade, and much more information has accumulated.2 3 4 5 Among more recent developments have been a number of investigations emphasizing the fact that the degree and nature of immunosuppression can vary greatly, depending on the antitumor agent and the animal species investigated.6 7 8 9 The immunologic effects of these compounds has provided a rationale for their use in the treatment of a variety of diseases assumed to have an immunologic pathogenesis. Encouraging results have been obtained in various autoimmune and collagen diseases.10 11 12 13 14 15 16 In addition, the suppression of kidney and hematopoietic . . .