Intravenous magnetic nanoparticle cancer hyperthermia
Open Access
- 1 July 2013
- journal article
- research article
- Published by Informa UK Limited in International Journal of Nanomedicine
- Vol. 8 (1), 2521-2532
- https://doi.org/10.2147/ijn.s43770
Abstract
Abstract: Magnetic nanoparticles heated by an alternating magnetic field could be used to treat cancers, either alone or in combination with radiotherapy or chemotherapy. However, direct intratumoral injections suffer from tumor incongruence and invasiveness, typically leaving undertreated regions, which lead to cancer regrowth. Intravenous injection more faithfully loads tumors, but, so far, it has been difficult achieving the necessary concentration in tumors before systemic toxicity occurs. Here, we describe use of a magnetic nanoparticle that, with a well-tolerated intravenous dose, achieved a tumor concentration of 1.9 mg Fe/g tumor in a subcutaneous squamous cell carcinoma mouse model, with a tumor to non-tumor ratio > 16. With an applied field of 38 kA/m at 980 kHz, tumors could be heated to 60°C in 2 minutes, durably ablating them with millimeter (mm) precision, leaving surrounding tissue intact.Keywords
This publication has 77 references indexed in Scilit:
- PEG/RGD-modified magnetic polymeric liposomes for controlled drug release and tumor cell targetingInternational Journal of Pharmaceutics, 2012
- Nanoparticle Actuated Hollow Drug Delivery VehiclesNanomedicine, 2011
- Magnetic multicore nanoparticles for hyperthermia—influence of particle immobilization in tumour tissue on magnetic propertiesNanotechnology, 2011
- Magnetic fluid hyperthermia: Focus on superparamagnetic iron oxide nanoparticlesAdvances in Colloid and Interface Science, 2011
- Magnetic nanomaterials for hyperthermia-based therapy and controlled drug deliveryAdvanced Drug Delivery Reviews, 2011
- Targeted hyperthermia using magnetite cationic liposomes and an alternating magnetic field in a mouse osteosarcoma modelThe Journal of Bone and Joint Surgery. British volume, 2010
- Effects of hyperthermia with dextran magnetic fluid on the growth of grafted H22 tumor in miceInternational Journal of Hyperthermia, 2009
- Anticancer effect and immune induction by hyperthermia of malignant melanoma using magnetite cationic liposomesMelanoma Research, 2003
- Inductive heating of ferrimagnetic particles and magnetic fluids: Physical evaluation of their potential for hyperthermiaInternational Journal of Hyperthermia, 1993
- Resection of Hepatic Metastases From Colorectal CancerArchives of Surgery, 1984