MAC of 1–653 in Beagle Dogs and New Zealand White Rabbits

Abstract

The minimum alveolar concentration (MAC) of I-653 was determined in six beagle dogs and four New Zealand white rabbits. The MAC values (.+-. SD) were 7.2 .+-. 1.0 atm % for dogs and 8.9 .+-. 0.3 atm % for rabbits. Comparison of these results with published MAC values for other anesthetics indicate that 1-653 is one-third to one-eighth as potent as currently available volatile anesthetics (enflurane, isoflurance, and halothane). From these data and previous reports, human MAC was projected to be approximately 5.1 atm %.