An inherited limb deformity created by insertional mutagenesis in a transgenic mouse
- 1 November 1985
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 318 (6041), 36-40
- https://doi.org/10.1038/318036a0
Abstract
We have created an insertional mutation that leads to a severe defect in the pattern of limb formation in the developing mouse. The novel recessive mutation is phenotypically identical and non-complementary to two previously encountered limb deformity mutations, and is closely linked to a dominant mutation that gives rise to a related limb dysmorphism. The inserted element thus provides a molecular genetic link with the control of pattern formation in the mammalian embryo.Keywords
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