Neutrophil influx into an inflammatory site inhibited by a soluble homing receptor–IgG chimaera
- 1 January 1991
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 349 (6305), 164-167
- https://doi.org/10.1038/349164a0
Abstract
Neutrophil-mediated inflammation is involved in a number of human clinical manifestations, including the adult respiratory distress syndrome, multi-organ failure and reperfusion injury. One way of inhibiting this type of inflammatory response would be to block competitively the adhesive interactions between neutrophils and the endothelium adjacent to the inflamed region. The lectin-containing murine adhesion molecule gp90MEL, the homing receptor, is found on all leukocytic cells, including neutrophils. MEL 14, a monoclonal antibody directed against this adhesion molecule, blocks lymphocyte traffic to lymph nodes and extravasation of neutrophils from blood to inflammatory sites. Here we show that administration to mice of a soluble immunoglobulin chimaera containing the murine homing receptor extracellular domain significantly decreases the number of neutrophils that migrate to the peritoneum in response to the inflammatory irritant thioglycollate. These results indicate that soluble forms of a single type of adhesion molecule, the homing receptor, could be clinically effective compounds for the inhibition of neutrophil-mediated inflammation.Keywords
This publication has 17 references indexed in Scilit:
- Adhesion receptors of the immune systemNature, 1990
- Regulation of Alloreactivity in Vivo by a Soluble Form of the Interleukin-1 ReceptorScience, 1990
- The Mel 14 antibody binds to the lectin domain of the murine peripheral lymph node homing receptor.The Journal of cell biology, 1990
- Mouse Lymph Node Homing Receptor cDNA Clone Encodes a Glycoprotein Revealing Tandem Interaction DomainsScience, 1989
- Endothelial Leukocyte Adhesion Molecule 1: an Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and LectinsScience, 1989
- Designing CD4 immunoadhesins for AIDS therapyNature, 1989
- Immunohistologic and functional characterization of a vascular addressin involved in lymphocyte homing into peripheral lymph nodes.The Journal of cell biology, 1988
- Neutralization of the AIDS Retrovirus by Antibodies to a Recombinant Envelope GlycoproteinScience, 1986
- Lymphocyte homing receptorsCell, 1986
- A cell-surface molecule involved in organ-specific homing of lymphocytesNature, 1983