Human recombinant interleukin 4 induces Fc epsilon R2/CD23 on normal human monocytes.
Open Access
- 1 April 1988
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 167 (4), 1406-1416
- https://doi.org/10.1084/jem.167.4.1406
Abstract
RIL-4 (B cell stimulatory factor 1) induces the expression of Fc epsilon R2/CD23 on normal human monocytes (Mo). Fc epsilon R2/CD23 induction was detectable both by flow cytometry using anti-CD23 mAbs as well as soluble IgE, and by the immunoprecipitation with CD23-specific mAb or IgE of a 45-kD band from 125I-lactoperoxidase-labeled Mo. Fc epsilon R2/CD23 was fully expressed after a 24-h incubation with rIL-4, and was still detectable after 72 h from the addition of IL-4. This effect was specific, because none of the other rILs tested (IL-1, IL-2, IL-3, IL-5, B cell stimulatory factor 2, granulocyte-macrophage colony stimulating factor, and IFN-gamma) could induce FC epsilon R2/CD23, either alone or in various combinations. No synergism was observed between IL-4 and other ILs. IFN-gamma was not able to inhibit the IL-4-induced expression of Fc epsilon R2/CD23 on Mo, neither when added to the culture together with IL-4, nor when added 36 h earlier.This publication has 34 references indexed in Scilit:
- The receptor with high affinity for immunoglobulin E.Annual Review of Immunology, 1986
- The receptor for IgE on blood plateletsEuropean Journal of Immunology, 1986
- BLAST-2 [EBVCS], an early cell surface marker of human B cell activation, is superinduced by Epstein Barr virus.The Journal of Immunology, 1985
- Role of IgE receptors in effector function of human eosinophils.The Journal of Immunology, 1984
- Structure and Function of Fc Receptors for IgE on Lymphocytes, Monocytes, and MacrophagesAdvances in Immunology, 1984
- Secretion of leukotriene C and other arachidonic acid metabolites by macrophages challenged with immunoglobulin E immune complexes.The Journal of Experimental Medicine, 1982
- Characterization of the target cell receptor for IgE. II. Polyacrylamide gel analysis of the surface IgE receptor from normal rat mast cells and from rat basophilic leukemia cells.1976
- Biology of immunoglobulin E. Molecular basis of reaginic hypersensitivity.1975
- Biologic function of the Fc fragments of E myeloma proteinImmunochemistry, 1970
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970