Sentinel Lymph Node Biopsy in Breast Cancer Patients by Means of Indocyanine Green Using the Karl Storz VITOM® Fluorescence Camera
Open Access
- 1 January 2018
- journal article
- research article
- Published by Hindawi Limited in BioMed Research International
- Vol. 2018, 1-8
- https://doi.org/10.1155/2018/6251468
Abstract
Currently, the use of radioisotope and blue dye for sentinel lymph node biopsy (SLNB) for axillary staging in breast cancer is common. Recently, indocyanine green (ICG) has been proposed as an alternative sentinel lymph node (SLN) tracking agent. We evaluated the clinical value of ICG as an additional tracer in combination with Technetium(99m) and as an alternative to Technetium(99m) for the identification of SLN in 104 breast cancer patients. 21 patients had at least 1 histologically tumor-positive SLN. All 21 patients were detected by ICG; in one of these 21 sentinel-positive patients, Technetium(99m) was unable to identify lymph node involvement. Our results show that ICG is as effective as the radioisotope for SLNB. In addition, as a near-infrared dye, it has the advantages of real-time visualization, lower cost, and wider availability, since no radioactive material needs to be handled.This publication has 35 references indexed in Scilit:
- Sentinel-lymph-node biopsy in patients with breast cancer before and after neoadjuvant chemotherapy (SENTINA): a prospective, multicentre cohort studyThe Lancet Oncology, 2013
- Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trialThe Lancet Oncology, 2010
- A Novel Method for Sentinel Lymph Node Biopsy by Indocyanine Green Fluorescence Technique in Breast CancerCancers, 2010
- Sentinel lymph node biopsy in breast cancer guided by indocyanine green fluorescenceBritish Journal of Surgery, 2009
- Lymphatic mapping and sentinel lymph node biopsy in early‐stage breast carcinomaCancer, 2005
- Evaluation of the Benefit of Using Blue Dye in Addition to Radioisotope for Sentinel Lymph Node Biopsy in Patients With Breast CancerThe Breast Journal, 2005
- Post-operative arm morbidity and quality of life. Results of the ALMANAC randomised trial comparing sentinel node biopsy with standard axillary treatment in the management of patients with early breast cancerBreast Cancer Research and Treatment, 2005
- A concept for the clinical implementation of sentinel lymph node biopsy in patients with breast carcinoma with special regard to quality assuranceCancer, 2005
- Sentinel-node biopsy for axillary staging in breast cancer: results from a large prospective German multi-institutional trialEuropean Journal of Surgical Oncology, 2004
- How many cases are enough for accreditation in sentinel lymph node biopsy in breast cancer?The American Journal of Surgery, 2003