The genome of equine herpesvirus type 2 harbors an interleukin 10 (IL10)-like gene
- 1 February 1993
- journal article
- research article
- Published by Springer Science and Business Media LLC in Virus Genes
- Vol. 7 (1), 111-116
- https://doi.org/10.1007/bf01702353
Abstract
A gene was identified within the DNA sequences of theEcoRI DNA fragment N (4.3 kbp) of the genome of equine herpesvirus type 2 (EHV-2) coding for a protein (179 amino acid residues) homologous to the cytokine synthesis inhibitory factor (CSIF; interleukin 10) of the human and mouse, and to the Epstein-Barr virus (EBV) protein BCRF1. This finding is further significant evidence that the interleukin 10 (IL-10) and/or IL-10-like gene can indeed be present in the genomes of members of the herpesviral family.Keywords
This publication has 23 references indexed in Scilit:
- Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.The Journal of Experimental Medicine, 1991
- Expression of Interleukin-10 Activity by Epstein-Barr Virus Protein BCRF1Science, 1990
- Identification of a novel thymocyte growth-promoting factor derived from B cell lymphomasCellular Immunology, 1990
- Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFIScience, 1990
- Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.The Journal of Experimental Medicine, 1989
- Physical mapping of a genome of equine herpesvirus 2 (equine cytomegalovirus)Archiv für die gesamte Virusforschung, 1989
- Lymphokine-mediated regulation of the proliferative response of clones of T helper 1 and T helper 2 cells.The Journal of Experimental Medicine, 1988
- Herpes Simplex and 'The Herpes Complex': Diverse Observations and A Unifying HypothesisJournal of General Virology, 1984
- DNA sequence and expression of the B95-8 Epstein—Barr virus genomeNature, 1984
- The use of thin acrylamide gels for DNA sequencingFEBS Letters, 1978