Maprouneacin, a New Daphnane Diterpenoid with Potent Antihyperglycemic Activity from Maprounea africana
- 4 December 1998
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 62 (2), 345-347
- https://doi.org/10.1021/np980356c
Abstract
Bioassay-guided fractionation of the EtOH extract of M. africana, using the in vivo noninsulin-dependent diabetes mellitus db/db mouse model, resulted in the isolation of the new daphnane-type diterpenoid maprouneacin (2). Compound 2 showed potent glucose-lowering properties when given by the oral route.Keywords
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