Inhibition of TNFα attenuates infarct volume and ICAM-1 expression in ischemic mouse brain
- 22 June 1998
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in NeuroReport
- Vol. 9 (9), 2131-2134
- https://doi.org/10.1097/00001756-199806220-00041
Abstract
THE purpose of our study was to determine whether inhibiting the action of tumor necrosis factor-α (TNFα) attenuates brain injury and reduces inflammatory responses in the mouse during ischemia and reperfusion. Mice underwent middle cerebral artery occlusion (MCAO) for 1 h followed by 23 h reperfusion. Monoclonal neutralizing anti-murine TNFα antibody (mAb) was administrated intraventricularly in the mouse with temporary MCAO. Infarct volume in the anti-TNFα mAb treated mice was significantly smaller than that in the control group (p < 0.05). The number of intercellular adhesion molecule-1 (ICAM-1)-positive vessels in the ischemic area of the anti-TNFα mAb-treated group was significantly less than that in the control group. Our study demonstrated that blocking TNFα reduced brain injury and attenuated ICAM-1 expression during transient cerebral ischemia.Keywords
This publication has 6 references indexed in Scilit:
- Inhibition of Tumor Necrosis Factor and Amelioration of Brain Infarction in MiceJournal of Cerebral Blood Flow & Metabolism, 1997
- TNF and Mae West or: death from too much of a good thingThe Lancet, 1995
- Leucocyte-endothelial interactions and regulation of leucocyte migrationThe Lancet, 1994
- In vivo relationship of tumor necrosis factor-α to blood-brain barrier damage in patients with active multiple sclerosisJournal of Neuroimmunology, 1992
- Cytokine regulation of endothelial cell functionThe FASEB Journal, 1992
- Cytokines and endothelial cell biologyPhysiological Reviews, 1990