Expression of Liver–Intestine Cadherin and Its Correlation with Lymph Node Metastasis in Gastric Cancer: Can It Predict N Stage Preoperatively?
- 25 October 2006
- journal article
- Published by Springer Science and Business Media LLC in Annals of Surgical Oncology
- Vol. 14 (1), 94-99
- https://doi.org/10.1245/s10434-006-9114-9
Abstract
Reliable method to predict lymph node metastasis is not yet available. In the present study, therefore, we examined LI-cadherin expression in human gastric cancer and attempted to find its relationship with clinicopathologic data, especially with lymph node metastasis. We also analyzed the expression in preoperative biopsy specimen to uncover its possibility of prognostication for lymph node metastasis. The paired preoperative endoscopic biopsy and postoperative resected specimens from 208 patients who had surgically been treated for gastric cancer were retrospectively analyzed immunohistochemically for expression of LI-cadherin. There were 47 (22.6%) and 161 (77.4%) tumors which had positive and negative LI-cadherin expression, respectively. LI-cadherin expression was significantly correlated with tumor histology and lymph node metastasis: Furthermore, reduced expression of LI-cadherin was closely associated with tumor progression and lymph node metastasis in human gastric carcinoma. LI-cadherin expressions in both resected tumor and preoperative endoscopic tissues were found to be independent factors associated with lymph node metastasis. There is a close association between reduced expression of LI-cadherin and lymph node metastasis in human gastric cancer. Immunohistochemical study of LI-cadherin is relatively simple compared to sentinel node navigation surgery, and it could be a practical prediction method for lymph node metastasis in patients with this malignancy.Keywords
This publication has 21 references indexed in Scilit:
- Reduced expression of liver–intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinomaCancer Letters, 2004
- Expression of liver-intestine cadherin and its possible interaction with galectin-3 in ductal adenocarcinoma of the pancreasCancer Science, 2003
- Abnormal expression of E-cadherin and β-catenin may be a molecular marker of submucosal invasion and lymph node metastasis in early gastric cancerBritish Journal of Surgery, 2002
- Influence of the number of lymph nodes examined on staging of gastric cancerBritish Journal of Surgery, 2001
- LI-cadherin: a marker of gastric metaplasia and neoplasiaGut, 2001
- Detection and Prediction of Micrometastasis in the Lymph Nodes of Patients With pN0 Gastric CancerAnnals of Surgical Oncology, 2001
- Cooccurrence of Reduced Expression of α-Catenin and Overexpression of p53 Is a Predictor of Lymph Node Metastasis in Early Gastric CancerOncology, 1999
- Liver-intestine cadherin: molecular cloning and characterization of a novel Ca(2+)-dependent cell adhesion molecule expressed in liver and intestine.The Journal of cell biology, 1994
- Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasivenessBiochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1994
- Cadherin Cell Adhesion Receptors as a Morphogenetic RegulatorScience, 1991