Concurrent Binding and Delivery of Proteins and Lipophilic Small Molecules Using Polymeric Nanogels
- 11 April 2012
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 134 (16), 6964-6967
- https://doi.org/10.1021/ja3019143
Abstract
Supramolecular nanoassemblies, which are capable of binding and delivering either lipophilic small molecules or hydrophilic molecules, are of great interest. Concurrently binding and delivering this combination of molecules is cumbersome, because of the opposing supramolecular host requirements. We describe the development of a versatile nanoassembly system that is capable of binding and delivering both, a protein and a lipophilic small molecule, simultaneously inside the cells.Keywords
This publication has 30 references indexed in Scilit:
- Synergistic Induction of Apoptosis in Brain Cancer Cells by Targeted Codelivery of siRNA and Anticancer DrugsMolecular Pharmaceutics, 2011
- Inflammation Responsive Logic Gate Nanoparticles for the Delivery of ProteinsBioconjugate Chemistry, 2011
- Surface Engineering of Iron Oxide Nanoparticles for Targeted Cancer TherapyAccounts of Chemical Research, 2011
- Noncovalent Encapsulation Stabilities in Supramolecular NanoassembliesJournal of the American Chemical Society, 2010
- UV and Near-IR Triggered Release from Polymeric NanoparticlesJournal of the American Chemical Society, 2010
- Self-assembled oligopeptide nanostructures for co-delivery of drug and gene with synergistic therapeutic effectBiomaterials, 2009
- Nanoparticle therapeutics: an emerging treatment modality for cancerNature Reviews Drug Discovery, 2008
- Enhanced Cell Penetration of Acid-Degradable Particles Functionalized with Cell-Penetrating PeptidesBioconjugate Chemistry, 2008
- Methodological and cellular aspects that govern the internalization mechanisms of arginine-rich cell-penetrating peptidesAdvanced Drug Delivery Reviews, 2007
- Determination and Modeling of Kinetics of Cancer Cell Killing by Doxorubicin and Doxorubicin Encapsulated in Targeted LiposomesCancer Research, 2004