Effect of Cholecystokinin and Pentagastrin on Motility and Gastric Secretion in the Cat

Abstract

The effects of cholecystokinin (CCK; 0.25 – 16 IDU kg^-1 h^-1), synthetic octapeptide of CCK (OP-CCK; 0.5–2 μg kg^-1 h^-1) and pentagastrin (0.5–8 μg kg^-1 h^-1) on pepsin secretion and antral motility were compared in conscious cats with reference to acid secretion. The results confirmed that the 3 peptides are full agonists for acid secretion and showed that they also displayed the same action on antral motor activity in increasing the frequency and decreasing the force of the contractions. Their effects on pepsin secretion were of different efficacy, decreasing from pentagastrin to CCK and to OP-CCK which showed a very weak action.