Biologically active sesquiterpene coumarins fromFerulaspecies
- 28 October 2010
- journal article
- review article
- Published by Wiley in Phytotherapy Research
- Vol. 25 (3), 315-323
- https://doi.org/10.1002/ptr.3311
Abstract
Extracts from different species of the genus Ferula (Apiaceae) have had various biomedical applications for many centuries. Many biological features of this genus such as cytotoxicity, antibacterial, antiviral, P‐glycoprotein (P‐gp) inhibitory and antiinflammatory activity have been attributed to sesquiterpene coumarins; structures containing a common coumarin group and a sesquiterpene moiety. This both highlights the importance of sesquiterpene coumarins as biologically active natural products and necessitates further studies on these compounds. Taking into account the versatile biological properties of compounds isolated from Ferula and the unprecedented interest in the application of natural products as a new generation of therapeutics, the present review will discuss reports on biological activities of sesquiterpene coumarins of the genus Ferula, from 1990 onwards. Copyright © 2010 John Wiley & Sons, Ltd.Keywords
This publication has 57 references indexed in Scilit:
- Cancer chemopreventive activity of the prenylated coumarin, umbelliprenin, in vivoEuropean Journal Of Cancer Prevention, 2009
- Influenza A (H1N1) Antiviral and Cytotoxic Agents from Ferula assa-foetidaJournal of Natural Products, 2009
- Evaluation of antigenotoxicity effects of umbelliprenin on human peripheral lymphocytes exposed to oxidative stressCell Biology and Toxicology, 2008
- LeukotrienesNew England Journal of Medicine, 2007
- New Tubulin Inhibitors from Plants – A Critical AssessmentChimia, 2007
- Biologic Therapy for Inflammatory Bowel DiseaseDrugs, 2005
- HPLC-DAD-MS identification of bioactive secondary metabolites from Ferula communis rootsFitoterapia, 2004
- Asafoetida inhibits early events of carcinogenesis: A chemopreventive studyLife Sciences, 2001
- Antinociceptive, Anti-Inflammatory and Antipyretic Effects of Lapidin, a Bicyclic Sesquiterpene*Planta Medica, 1994
- Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and InflammationScience, 1983