ras Oncogene p21 expression is increased in premalignant lesions and high grade bladder carcinoma.
Open Access
- 1 May 1985
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 161 (5), 1213-1218
- https://doi.org/10.1084/jem.161.5.1213
Abstract
Ras Oncogene p21 antigen is present in the most superficial cells of the normal bladder urothelium, as demonstrated by immunohistochemical staining. The pattern and intensity of p21 staining of cells in epithelial hyperplasia and low grade bladder carcinoma were similar to that seen in the normal urothelium. In contrast, epithelial cells in "premalignant" (dysplastic) lesions and high grade carcinomas exhibited an intense staining reaction for p21 antigen. ras p21 may be a useful marker for the malignant potential of both premalignant lesions and carcinomas of the bladder.Keywords
This publication has 17 references indexed in Scilit:
- Ha-ras oncogenes are activated by somatic alterations in human urinary tract tumoursNature, 1984
- Expression of Cellular Oncogenes in Human MalignanciesScience, 1984
- Mutation Affecting the 12th Amino Acid of the c-Ha- ras Oncogene Product Occurs Infrequently in Human CancerScience, 1983
- Expression of a Cellular Oncogene During Liver RegenerationScience, 1983
- Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid changeNature, 1982
- A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogeneNature, 1982
- Mechanism of activation of a human oncogeneNature, 1982
- Biological Diversity in Metastatic Neoplasms: Origins and ImplicationsScience, 1982
- Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virusNature, 1982
- Localization of the src gene product of the Harvey strain of MSV to plasma membrane of transformed cells by electron microscopic immunocytochemistryCell, 1980