Autophagy-Dependent Viral Recognition by Plasmacytoid Dendritic Cells
- 9 March 2007
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 315 (5817), 1398-1401
- https://doi.org/10.1126/science.1136880
Abstract
Plasmacytoid dendritic cells (pDCs) detect viruses in the acidified endosomes by means of Toll-like receptors (TLRs). Yet, pDC responses to certain single-stranded RNA (ssRNA) viruses occur only after live viral infection. We present evidence here that the recognition of such viruses by TLR7 requires transport of cytosolic viral replication intermediates into the lysosome by the process of autophagy. In addition, autophagy was found to be required for the production of interferon-α by pDCs. These results support a key role for autophagy in mediating ssRNA virus detection and interferon-α secretion by pDCs and suggest that cytosolic replication intermediates of viruses serve as pathogen signatures recognized by TLR7.Keywords
This publication has 29 references indexed in Scilit:
- RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-PhosphatesScience, 2006
- 5'-Triphosphate RNA Is the Ligand for RIG-IScience, 2006
- Subversion of Cellular Autophagosomal Machinery by RNA VirusesPLoS Biology, 2005
- The role of autophagy during the early neonatal starvation periodNature, 2004
- Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8Science, 2004
- Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNAScience, 2004
- In Vivo Analysis of Autophagy in Response to Nutrient Starvation Using Transgenic Mice Expressing a Fluorescent Autophagosome MarkerMolecular Biology of the Cell, 2004
- Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic CellsThe Journal of Experimental Medicine, 2003
- LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processingThe EMBO Journal, 2000
- Splenic Marginal Metallophilic Macrophages and Marginal Zone Macrophages are the Major Interferon‐α/β Producers in Mice upon Intravenous Challenge with Herpes Simplex VirusScandinavian Journal of Immunology, 1999