The control of human pancreatic adenocarcinoma xenografts in nude mice by hormone therapy
- 1 October 1982
- journal article
- research article
- Published by Oxford University Press (OUP) in British Journal of Surgery
- Vol. 69 (10), 595-597
- https://doi.org/10.1002/bjs.1800691013
Abstract
The effect of hormone therapy on the growth of human non-endocrine pancreatic adenocarcinoma xenografts in nude mice was evaluated. The androgen testosterone stimulated tumour growth rate, whereas the anti-androgen cyproterone acetate significantly inhibited tumour growth rate compared with untreated controls. These findings provide further support for the suggestion that the growth and metabolism of pancreatic carcinoma may be dependent on the sex steroid hormones.Keywords
Funding Information
- Cancer Research Campaign
- Ned Foundation
- Frances and Augustus Newman Foundation
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